The Puerto Rican singer and rapper announced this on stage during the final day of his farewell tour, La Meta, in Puerto Rico over the weekend.
He said he now hopes to “evangelize the world” and live for Jesus.
In a video message shared via his Instagram page, ‘The King Of Reggaeton’ said that a part of him felt empty and he had been trying to fill a void in his life for a long time that no one could fill.
In his message, the ‘Despacito’ crooner cited a Bible verse; “I was able to travel the world for years winning many awards, applause and praise, but I realized something that the Bible says, ‘what good is it for a man to gain the whole world if he forfeits his soul?’”
He added: “One story is over and a new story is going to begin, a new beginning.”
Daddy Yankee began his career in 1994 and is regarded as one of the pioneers of the reggaeton genre.
He retired at the age of 46.