The Dawson’s Creek actress, 44, was promoting her new film Rare Objects – which she directed – with the publication when she spoke about family and her rise to fame.
In the film there is an early scene where the young lead Benita played by Julia Mayorga is assaulted.
She said of shooting the sensitive moment: ‘What was most important to me was what it did to [Benita] in the aftermath. To me, unfortunately, [sexual assault] is an understood secret amongst women, so we don’t have to share too much to know what we’re talking about.
Julia was so incredible in that scene, and that was really a difficult one to shoot because I just needed her face.
‘I kept telling both of the actors, ‘It’s your faces.’ And so they had to really go there. Everybody was pretty shaken up after.’
Rare Objects is based on Kathleen Tessaro’s novel of the same name, which was released in 2016.
Although the book takes place just after the Great Depression, Holmes’ movie is set in modern-day New York City.
The movie is centered on a young woman who attempts to rebuild her life by working in an antique store before various figures from her past begin to resurface.
Katie looked incredible for the Glamour cover wearing a sheer black and white top with gold detailing and sporting a nose ring.
Other looks saw her pose in a cut-out gold dress with a statement belt before changing into a quirky white corset top and grey trousers.
Elsewhere during the interview she gave a rare insight into family life with her 16-year-old daughter Suri – who she shares with ex-husband Tom Cruise.
She said it has been very important to ‘protect her’ due to her only child being ‘so visible at a young age’.
Katie added that she was ‘grateful’ to be her parent because she is such an ‘incredible person’.
It was reported earlier this month that Suri has now started applying to colleges with the help of her mother – but the teen’s famous father Tom won’t have a hand in helping her, because the actor ‘has no part’ in his child’s life.
Katie was given ‘sole custody’ of Suri and according to their divorce documents, Tom agreed to pay Katie $400,000 a year until Suri turned 18 years old.
Suri has not seen her Mission Impossible star father in a decade after he went MIA when Katie refused to join The Church of Scientology.
Katie’s new film Rare Objects will be released both in theaters and on demand on Friday.